Article
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
Diabetes - 1 May 2013
Saxena Richa, Saleheen Danish, Been Latonya F, Garavito Martha L, Braun Timothy, Bjonnes Andrew, Young Robin, Ho Weang Kee, Rasheed Asif, Frossard Philippe, Sim Xueling, Hassanali Neelam, Radha Venkatesan, Chidambaram Manickam, Liju Samuel, Rees Simon D, Ng Daniel Peng-Keat, Wong Tien-Yin, Yamauchi Toshimasa, Hara Kazuo, Tanaka Yasushi, Hirose Hiroshi, McCarthy Mark I, Morris Andrew P, Basit Abdul, Barnett Anthony H, Katulanda Prasad, Matthews David, Mohan Viswanathan, Wander Gurpreet S, Singh Jai Rup, Mehra Narinder K, Ralhan Sarju, Kamboh M Ilyas, Mulvihill John J, Maegawa Hiroshi, Tobe Kazuyuki, Maeda Shiro, Cho Yoon S, Tai E Shyong, Kelly M Ann, Chambers John C, Kooner Jaspal S, Kadowaki Takashi, Deloukas Panos, Rader Daniel J, Danesh John, Sanghera Dharambir K
Abstract excerpt
We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs) (P < 10⁻³) in Punjabi Sikhs (n = 2,819; 801 case subjects). We further replicated 66 SNPs (P < 10⁻⁴) through...
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