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Article

Conditional Loss of Arx From the Developing Dorsal Telencephalon Results in Behavioral Phenotypes Resembling Mild Human ARX Mutations.

Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 2015

Simonet Jacqueline C, Sunnen C Nicole, Wu Jue, Golden Jeffrey A, Marsh Eric D

Abstract excerpt

Mutations in the Aristaless-Related Homeobox (ARX) gene cause structural anomalies of the brain, epilepsy, and neurocognitive deficits in children. During forebrain development, Arx is expressed in both pallial and subpallial progenitor cells. We previously demonstrated that elimination of Arx from subpallial-derived cortical interneurons generates an epilepsy phenotype with features overlapping those seen in...

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Identifiers

PMID: 24794919
DOI: 10.1093/cercor/bhu090
PMCID: PMC4537438

Genes

ARX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Conditional Loss of Arx From the Developing Dorsal Telencephalon Results in Behavioral Phenotypes Resembling Mild Human ARX Mutations.PMID 24794919Read ↗

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