Article
Aristaless-related homeobox gene disruption leads to abnormal distribution of GABAergic interneurons in human neocortex: evidence based on a case of X-linked lissencephaly with abnormal genitalia (XLAG).
Acta neuropathologica - 1 Oct 2008
Okazaki Shin, Ohsawa Maki, Kuki Ichiro, Kawawaki Hisashi, Koriyama Takeshi, Ri Shingou, Ichiba Hiroyuki, Hai Eishu, Inoue Takeshi, Nakamura Hiroaki, Goto Yu-Ichi, Tomiwa Kiyotaka, Yamano Tsunekazu, Kitamura Kunio, Itoh Masayuki
Abstract excerpt
X-linked lissencephaly with abnormal genitalia (XLAG) is a rare disorder caused by mutations in the aristaless-related homeobox (ARX) gene, located on Xp22.13. Arx-null mice show loss of tangential migration of GABAergic interneurons, presumably being related to caudal ganglionic eminence tangential migration. In the present study, we investigated a subpopulation of GABAergic interneurons in the brain of an...
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