Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.

doi:10.1038/ng1009

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Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.

Nature genetics - 1 Nov 2002

Kitamura Kunio, Yanazawa Masako, Sugiyama Noriyuki, Miura Hirohito, Iizuka-Kogo Akiko, Kusaka Masatomo, Omichi Kayo, Suzuki Rika, Kato-Fukui Yuko, Kamiirisa Kyoko, Matsuo Mina, Kamijo Shin-ichi, Kasahara Megumi, Yoshioka Hidefumi, Ogata Tsutomu, Fukuda Takayuki, Kondo Ikuko, Kato Mitsuhiro, Dobyns William B, Yokoyama Minesuke, Morohashi Ken-ichirou

Abstract excerpt

Male embryonic mice with mutations in the X-linked aristaless-related homeobox gene (Arx) developed with small brains due to suppressed proliferation and regional deficiencies in the forebrain. These mice also showed aberrant migration and differentiation of interneurons containing gamma-aminobutyric acid (GABAergic interneurons) in the ganglionic eminence and neocortex as well as abnormal testicular...

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PMID: 12379852
DOI: 10.1038/ng1009

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Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans.PMID 12379852Read ↗

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