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Article

Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females.

Brain : a journal of neurology - 1 Jun 2009

Marsh Eric, Fulp Carl, Gomez Ernest, Nasrallah Ilya, Minarcik Jeremy, Sudi Jyotsna, Christian Susan L, Mancini Grazia, Labosky Patricia, Dobyns William, Brooks-Kayal Amy, Golden Jeffrey A

Abstract excerpt

Mutations in the X-linked aristaless-related homeobox gene (ARX) have been linked to structural brain anomalies as well as multiple neurocognitive deficits. The generation of Arx-deficient mice revealed several morphological anomalies, resembling those observed in patients and an interneuron migration defect but perinatal lethality precluded analyses of later phenotypes. Interestingly, many of the neurological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19439424
DOI: 10.1093/brain/awp107
PMCID: PMC2685924

Genes

ARX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females.PMID 19439424Read ↗

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