Article
Correlation between genetic variations in Hox clusters and Hirschsprung's disease.
Annals of human genetics - 1 Jul 2007
Garcia-Barceló M M, Miao X, Lui V C H, So M T, Ngan E S W, Leon T Y Y, Lau D K C, Liu T T, Lao X, Guo W, Holden W T, Moore J, Tam P K H
Abstract excerpt
Interactions between migrating neural crest cells and the environment of the gut are crucial for the development of the enteric nervous system (ENS). A key signalling mediator is the RET-receptor-tyrosine-kinase which, when defective, causes Hirschprung's disease (HSCR, colon aganglionosis). RET mutations alone cannot account for the variable HSCR phenotype, invoking interactions with as yet unknown, and probably...
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