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Article

A strong interferon response correlates with a milder dengue clinical condition.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jul 2014

De La Cruz Hernández Sergio Isaac, Puerta-Guardo Henry, Flores-Aguilar Hilario, González-Mateos Silvia, López-Martinez Irma, Ortiz-Navarrete Vianney, Ludert Juan E, Del Angel Rosa María

Abstract excerpt

BACKGROUND: Type 1 interferon (IFNα/β) has a significant role in establishing protection against virus infections. It has been well documented by in vitro studies that dengue virus (DENV) activates a robust IFNα/β response. However, DENV also induces a down-regulation of the JAK/STAT pathway, inhibiting the induction of interferon regulated genes. As a consequence, the role played by the IFN type 1 response in...

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Identifiers

PMID: 24793964
DOI: 10.1016/j.jcv.2014.04.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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