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Gene Expression Profiling during Early Acute Febrile Stage of Dengue Infection Can Predict the Disease Outcome

19 Nov 2009

Abstract excerpt

BACKGROUND: We report the detailed development of biomarkers to predict the clinical outcome under dengue infection. Transcriptional signatures from purified peripheral blood mononuclear cells were derived from whole-genome gene-expression microarray data, validated by quantitative PCR and tested in independent samples. METHODOLOGY/PRINCIPAL FINDINGS: The study was performed on patients of a well-characterized...

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PMID: 19936257
DOI: 10.1371/journal.pone.0007892

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