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High-Confidence Glycosome Proteome for Procyclic Form <i>Trypanosoma brucei</i> by Epitope-Tag Organelle Enrichment and SILAC Proteomics

5 May 2014

Abstract excerpt

The glycosome of the pathogenic African trypanosome Trypanosoma brucei is a specialized peroxisome that contains most of the enzymes of glycolysis and several other metabolic and catabolic pathways. The contents and transporters of this membrane-bounded organelle are of considerable interest as potential drug targets. Here we use epitope tagging, magnetic bead enrichment, and SILAC quantitative proteomics to...

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PMID: 24792668
DOI: 10.1021/pr401209w

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