Article
Tumour necrosis factor -308 and -238 promoter polymorphisms are predictors of a null virological response in the treatment of Brazilian hepatitis C patients.
Memorias do Instituto Oswaldo Cruz - 1 Jun 2014
Grandi Tarciana, Silva Cláudia Maria Dornelles da, Amaral Karine Medeiros, Picon Paulo Dornelles, Costi Cintia, Fré Nicole Nascimento da, Fiegenbaum Marilu, Gregianini Tatiana Schäffer, Niel Christian, Rossetti Maria Lucia Rosa
Abstract excerpt
Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs in the promoters of interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) and tumour necrosis factor (TNF) (-308 G/A, rs1800629 and -238 G/A, rs361525) genes and...