Article
Association between HLA-DQA1/DRB1 polymorphism and development of hepatocellular carcinoma during entecavir treatment.
Journal of gastroenterology and hepatology - 1 May 2019
Kozuka Ritsuzo, Enomoto Masaru, Sato-Matsubara Misako, Yoshida Kanako, Motoyama Hiroyuki, Hagihara Atsushi, Fujii Hideki, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Tamori Akihiro, Kawada Norifumi, Murakami Yoshiki
Abstract excerpt
BACKGROUND AND AIMS: It remains unclear whether there is an association between single-nucleotide polymorphisms (SNPs) and development of hepatocellular carcinoma (HCC) during entecavir (ETV) treatment in nucleos(t)ide analog-naïve patients with chronic hepatitis B virus infection. We investigate...
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Female
- Fibrosis
- Genome-Wide Association Study
- Genotype
- Guanine
- HLA-DQ alpha-Chains
- HLA-DRB1 Chains
- Hepatitis B, Chronic
- Humans
- Liver
- Liver Neoplasms