Article
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias.
The Journal of experimental medicine - 9 May 2011
Shochat Chen, Tal Noa, Bandapalli Obul R, Palmi Chiara, Ganmore Ithamar, te Kronnie Geertruy, Cario Gunnar, Cazzaniga Giovanni, Kulozik Andreas E, Stanulla Martin, Schrappe Martin, Biondi Andrea, Basso Giuseppe, Bercovich Dani, Muckenthaler Martina U, Izraeli Shai
Abstract excerpt
Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency. Here, we describe somatic gain-of-function mutations in IL7R in pediatric B and T acute lymphoblastic leukemias. The mu...
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