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Article

Role of mutations in the cellular internalization of amyloidogenic light chains into cardiomyocytes.

Scientific reports - 1 Jan 2013

Levinson Rebecca T, Olatoye Oludare O, Randles Edward G, Howell Kyle G, DiCostanzo Ara Celi, Ramirez-Alvarado Marina

Abstract excerpt

Light chain (AL) amyloidosis is characterized by the misfolding of immunoglobulin light chains, accumulating as amyloid fibrils in vital organs. Multiple reports have indicated that amyloidogenic light chains internalize into a variety of cell types, but these studies used urine-derived proteins without indicating any protein sequence information. As a result, the role of somatic mutations in amyloidogenic...

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Share to Amyloidogenic Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Immunoglobulin Light Chains

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Share to Myocytes, Cardiac

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Identifiers

PMID: 23417147
DOI: 10.1038/srep01278
PMCID: PMC3575045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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