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Article

Metabolic imaging across scales reveals distinct prostate cancer phenotypes.

Nature communications - 16 Jul 2024

Sushentsev Nikita, Hamm Gregory, Flint Lucy, Birtles Daniel, Zakirov Aleksandr, Richings Jack, Ling Stephanie, Tan Jennifer Y, McLean Mary A, Ayyappan Vinay, Horvat Menih Ines, Brodie Cara, Miller Jodi L, Mills Ian G, Gnanapragasam Vincent J, Warren Anne Y, Barry Simon T, Goodwin Richard J A, Barrett Tristan, Gallagher Ferdia A

Abstract excerpt

Hyperpolarised magnetic resonance imaging (HP-13C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechanisms underpinning differential [1-13C]lactate labelling between benign and malignant prostate, as well as in tumours containing cribriform and non-cribriform Gleason pattern 4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39013948
DOI: 10.1038/s41467-024-50362-5
PMCID: PMC11252279

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HP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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