Article
Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome.
Blood - 12 Jun 2014
Martínez-Trillos Alejandra, Pinyol Magda, Navarro Alba, Aymerich Marta, Jares Pedro, Juan Manel, Rozman María, Colomer Dolors, Delgado Julio, Giné Eva, González-Díaz Marcos, Hernández-Rivas Jesús M, Colado Enrique, Rayón Consolación, Payer Angel R, Terol Maria José, Navarro Blanca, Quesada Victor, Puente Xosé S, Rozman Ciril, López-Otín Carlos, Campo Elías, López-Guillermo Armando, Villamor Neus
Abstract excerpt
Mutations in Toll-like receptor (TLR) and myeloid differentiation primary response 88 (MYD88) genes have been found in chronic lymphocytic leukemia (CLL) at low frequency. We analyzed the incidence, clinicobiological characteristics, and outcome of patients with TLR/MYD88 mutations in 587 CLL patients. Twenty-three patients (3.9%) had mutations, 19 in MYD88 (one with concurrent IRAK1 mutation), 2 TLR2 (one with...
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