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Article

Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation.

International journal of cancer - 1 Mar 2010

Rozková Daniela, Novotná Linda, Pytlík Robert, Hochová Ivana, Kozák Tomás, Bartůnková Jirina, Spísek Radek

Abstract excerpt

Toll-like receptor (TLR) stimulation plays a crucial role in the homeostasis of human B cells. We investigated the expression of TLRs 1-9 on the cells of B-cell chronic lymphocytic leukemia (B-CLL) and analyzed the functional consequences of TLR stimulation on leukemic cells. We showed that B-CLL cells express similar set of TLRs as memory B cells of healthy donors, i.e. TLR-1, TLR-2, TLR-6, TLR-7 and TLR-9....

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Source

Identifiers

PMID: 19685493
DOI: 10.1002/ijc.24832

Genes

TLR2
TLR1
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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