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Article

Clinicopathological characterization of chronic lymphocytic leukemia with MYD88 mutations: L265P and non-L265P mutations are associated with different features.

Blood cancer journal - 26 Aug 2020

Shuai Wen, Lin Pei, Strati Paolo, Patel Keyur P, Routbort Mark J, Hu Shimin, Wei Peng, Khoury Joseph D, You M James, Loghavi Sanam, Tang Zhenya, Fang Hong, Thakral Beenu, Medeiros L Jeffrey, Wang Wei

Abstract excerpt

MYD88 mutations in chronic lymphocytic leukemia (CLL) are not well characterized. Earlier reports yielded conflicting results in terms of clinicopathologic presentation and prognostic impact of MYD88 mutations in CLL patients. In addition, the morphological and immunophenotypic features of CLL cases carrying MYD88 mutations have not been explored. Finally, the clinical or biologic implications of the canonical...

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Identifiers

PMID: 32848129
DOI: 10.1038/s41408-020-00351-w
PMCID: PMC7450076

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