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Article

Heterogeneity and Targeting of Pancreatic Cancer Stem Cells

14 Aug 2012

Abstract excerpt

Cancer stem cells (CSC) have been identified in an ever-increasing number of human malignancies on the basis of their ability to recapitulate tumors in the ectopic setting and maintain long-term tumorigenic potential. In addition, in pancreatic adenocarcinoma, CSCs may display additional properties, such as relative drug resistance and enhanced invasive and migratory potential that implicate a role in disease...

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PMID: 22896694
DOI: 10.1158/1078-0432.ccr-11-3112

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