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Article

Importance of EGFR/ERCC1 Interaction Following Radiation-Induced DNA Damage

30 Apr 2014

Abstract excerpt

PURPOSE: The epidermal growth factor receptor (EGFR) plays an important role in cellular response to chemotherapy and radiotherapy through modulation of DNA repair. EGFR activates DNA-dependent protein kinase (DNA-PK) stimulating repair of DNA strand breaks (SB) and interstrand crosslinks (ICL). We investigated the role of EGFR in repair of ionizing radiation (IR)-induced SB independently of DNA-PK. EXPERIMENTAL...

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PMID: 24780295
DOI: 10.1158/1078-0432.ccr-13-2695

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