MAPK dependence of DNA damage repair: ionizing radiation and the induction of expression of the DNA repair genes XRCC1 and ERCC1 in DU145 human prostate carcinoma cells in a MEK1/2 dependent fashion

Abstract excerpt

PURPOSE: To examine the role of mitogen-activated protein kinase (MAPK) signalling on the induction by ionizing radiation of the nucleotide excision repair gene (ERCC1), the X-ray cross-complementing group 1 protein (XRCC1) and the repair of radiation-induced DNA damage. MATERIALS AND METHODS: The expression of ERCC1 and XRCC1 was examined in DU145 human prostate cancer cells following exposure to ionizing...

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