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Article

Power analysis and sample size estimation for sequence-based association studies.

Bioinformatics (Oxford, England) - 15 Aug 2014

Wang Gao T, Li Biao, Santos-Cortez Regie P Lyn, Peng Bo, Leal Suzanne M

Abstract excerpt

MOTIVATION: Statistical methods have been developed to test for complex trait rare variant (RV) associations, in which variants are aggregated across a region, which is typically a gene. Power analysis and sample size estimation for sequence-based RV association studies are challenging because of the necessity to realistically model the underlying allelic architecture of complex diseases within a suitable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24778108
DOI: 10.1093/bioinformatics/btu296
PMCID: PMC4133582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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