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Article

Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools.

Molecular and cellular biology - 1 Jul 2014

Lee Seakwoo, Henderson Mark J, Schiffhauer Eric, Despanie Jordan, Henry Katherine, Kang Po Wei, Walker Douglas, McClure Michelle L, Wilson Landon, Sorscher Eric J, Zeitlin Pamela L

Abstract excerpt

It is recognized that both wild-type and mutant CFTR proteins undergo ubiquitination at multiple lysines in the proteins and in one or more subcellular locations. We hypothesized that ubiquitin is added to specific sites in wild-type CFTR to stabilize it and at other sites to signal for proteolysis. Mass spectrometric analysis of wild-type CFTR identified ubiquitinated lysines 68, 710, 716, 1041, and 1080. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24777605
DOI: 10.1128/MCB.01042-13
PMCID: PMC4097669

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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