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Article

Effect of the Brugada syndrome mutation A39V on calmodulin regulation of Cav1.2 channels.

Molecular brain - 28 Apr 2014

Simms Brett A, Souza Ivana Assis, Zamponi Gerald W

Abstract excerpt

BACKGROUND: The L-type calcium channel Cav1.2 is important for brain and heart function. The ubiquitous calcium sensing protein calmodulin (CaM) regulates calcium dependent gating of Cav1.2 channels by reducing calcium influx, a process known as calcium-dependent inactivation (CDI). Dissecting the calcium-dependence of CaM in this process has benefited greatly from the use of mutant CaM molecules which are unable...

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Identifiers

PMID: 24775099
DOI: 10.1186/1756-6606-7-34
PMCID: PMC4012176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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