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Article

Association of genetic variants of xenobiotic metabolic pathway with systemic lupus erythematosus.

Indian journal of biochemistry & biophysics - 1 Oct 2013

Rupasree Yedluri, Naushad Shaik Mohammad, Rajasekhar Liza, Kutala Vijay Kumar

Abstract excerpt

In view of documented evidence that catechol estrogen-DNA adducts serve as epitopes for binding of anti-nuclear antibodies, genetic polymorphisms of the xenobiotic metabolic pathway involved in estrogen metabolism might contribute towards pathophysiology of systemic lupus erythematosus (SLE). To test this hypothesis, a case-control study was conducted. Cytochrome P 450 1A1 (CYP1A1) m4 (OR: 4.93, 95% CI:...

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PMID: 24772967

Genes

COMT
GSTT1
GSTM1

Variants

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