Article
Conditional independence mapping of DIGE data reveals PDIA3 protein species as key nodes associated with muscle aerobic capacity.
Journal of proteomics - 25 Jun 2014
Burniston Jatin G, Kenyani Jenna, Gray Donna, Guadagnin Eleonora, Jarman Ian H, Cobley James N, Cuthbertson Daniel J, Chen Yi-Wen, Wastling Jonathan M, Lisboa Paulo J, Koch Lauren G, Britton Steven L
Abstract excerpt
Profiling of protein species is important because gene polymorphisms, splice variations and post-translational modifications may combine and give rise to multiple protein species that have different effects on cellular function. Two-dimensional gel electrophoresis is one of the most robust methods for differential analysis of protein species, but bioinformatic interrogation is challenging because the consequences...
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