Article
Molecular Signatures of Membrane Protein Complexes Underlying Muscular Dystrophy.
Molecular & cellular proteomics : MCP - 1 Jun 2016
Turk Rolf, Hsiao Jordy J, Smits Melinda M, Ng Brandon H, Pospisil Tyler C, Jones Kayla S, Campbell Kevin P, Wright Michael E
Abstract excerpt
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating new DGC components. Establishment of the molecular composition of plasma-membrane protein complexes has been...
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