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Article

Clinical, molecular, and T cell subset analyses in a small cohort of Chinese patients with hyper-IgM syndrome type 1.

Human immunology - 1 Jul 2014

Tang Wen-Jing, An Yun-Fei, Dai Rong-Xin, Wang Qing-Hong, Jiang Li-Ping, Tang Xue-Mei, Yang Xi-Qiang, Yu Jie, Tu Wen-Wei, Zhao Xiao-Dong

Abstract excerpt

Type 1 hyper-IgM syndrome (HIGM1) is a rare primary immunodeficiency disease caused by mutations in the CD40L gene. Patients often present with recurrent infections and autoimmune manifestations. We investigated the clinical and molecular characteristics of HIGM1 in thirteen patients from the Chinese mainland and examined the proportion of CD4(+)CD25(+)FoxP3(+)Treg, Th17, and Th1 cells in the peripheral blood. We...

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Identifiers

PMID: 24768948
DOI: 10.1016/j.humimm.2014.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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