Defective expression of CD40 ligand on T cells causes "X-linked immunodeficiency with hyper-IgM (HIGM1)".

doi:10.1111/j.1600-065x.1994.tb00846.x

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Article

Defective expression of CD40 ligand on T cells causes "X-linked immunodeficiency with hyper-IgM (HIGM1)".

Immunological reviews - 1 Apr 1994

Kroczek R A, Graf D, Brugnoni D, Giliani S, Korthüer U, Ugazio A, Senger G, Mages H W, Villa A, Notarangelo L D

Abstract excerpt

X-linked immunodeficiency with hyper-IgM (HIGM1) is a rare disorder, characterized by recurrent infections associated with very low or absent IgG and IgA, and normal to increased IgM serum levels. The disease has been earlier mapped to the q26-27 region of the X-chromosome. We have identified a n...

Topics

Antigens, Differentiation, T-Lymphocyte
CD40 Ligand
Gene Expression Regulation
Genetic Linkage
Humans
Hypergammaglobulinemia
Immunoglobulin M
Immunologic Deficiency Syndromes
Ligands
Membrane Glycoproteins
Mutation
X Chromosome

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Identifiers

PMID: 7915248
DOI: 10.1111/j.1600-065x.1994.tb00846.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7915248-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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