Article
Mannose-binding lectin 2 gene polymorphism and lung damage in primary ciliary dyskinesia.
Pediatric pulmonology - 1 Feb 2015
Pifferi Massimo, Bush Andrew, Michelucci Angela, Di Cicco Maria, Piras Martina, Caramella Davide, Mazzei Federica, Neri Maria, Pioggia Giovanni, Tartarisco Gennaro, Saggese Giuseppe, Simi Paolo, Boner Attilio L
Abstract excerpt
BACKGROUND: Mannose-binding lectin (MBL) plays an important role in innate immunity and has been reported to be associated with the age-related decline in lung function in cystic fibrosis. HYPOTHESIS: MBL polymorphisms are associated with lung function decline in Primary Ciliary Dyskinesia (PCD). METHODS: We performed sputum microbiology, spirometry pre- and post-administration of salbutamol, ciliary motion...
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