Article
Complex two-gene modulation of lung disease severity in children with cystic fibrosis.
The Journal of clinical investigation - 1 Mar 2008
Dorfman Ruslan, Sandford Andrew, Taylor Chelsea, Huang Baisong, Frangolias Daisy, Wang Yongqian, Sang Richard, Pereira Lilian, Sun Lei, Berthiaume Yves, Tsui Lap-Chee, Paré Peter D, Durie Peter, Corey Mary, Zielenski Julian
Abstract excerpt
Although cystic fibrosis (CF) is a monogenic disease, its clinical manifestations are influenced in a complex manner. Severity of lung disease, the main cause of mortality among CF patients, is likely modulated by several genes. The mannose-binding lectin 2 (MBL2) gene encodes an innate immune response protein and has been implicated as a pulmonary modifier in CF. However, reports have been conflicting, and...
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