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Article

Alcohol Alters DNA Methylation Patterns and Inhibits Neural Stem Cell Differentiation

11 Jan 2011

Abstract excerpt

BACKGROUND: Potential epigenetic mechanisms underlying fetal alcohol syndrome (FAS) include alcohol-induced alterations of methyl metabolism, resulting in aberrant patterns of DNA methylation and gene expression during development. Having previously demonstrated an essential role for epigenetics in neural stem cell (NSC) development and that inhibiting DNA methylation prevents NSC differentiation, here we...

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Share to Neonatal and fetal brain pathology
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PMID: 21223309
DOI: 10.1111/j.1530-0277.2010.01391.x

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