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Article

IRGM promotes the PINK1‐mediated mitophagy through the degradation of Mitofilin in SH‐SY5Y cells

16 Sept 2020

Abstract excerpt

Mitochondria is a double membrane-bound cellular organelle that generates energy to maintain the homeostasis of cells. Immunity-related GTPase M (IRGM) in human locates at the inner membrane of mitochondria and is best known for its role in regulating autophagy against intracellular pathogens. Previous studies have shown that IRGM is crucial for the normal function of mitochondria, yet, the molecular mechanisms...

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PMID: 32939830
DOI: 10.1096/fj.202000943rr

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