Article
von Willebrand disease and aging: an evolving phenotype.
Journal of thrombosis and haemostasis : JTH - 1 Jul 2014
Sanders Y V, Giezenaar M A, Laros-van Gorkom B A P, Meijer K, van der Bom J G, Cnossen M H, Nijziel M R, Ypma P F, Fijnvandraat K, Eikenboom J, Mauser-Bunschoten E P, Leebeek F W G
Abstract excerpt
BACKGROUND: Because the number of elderly von Willebrand disease (VWD) patients is increasing, the pathophysiology of aging in VWD has become increasingly relevant. OBJECTIVES: To assess age-related changes in von Willebrand factor (VWF) and factor VIII (FVIII) levels and to compare age-related differences in bleeding phenotype between elderly VWD patients and those < 65 years. We also studied co-morbidity in...
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