Article
Plasma levels of plasminogen activator inhibitor-1 and bleeding phenotype in patients with von Willebrand disease.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2017
Abdul S, Boender J, Malfliet J J M C, Eikenboom J, Fijn van Draat K, Mauser-Bunschoten E P, Meijer K, de Meris J, Laros-van Gorkom B A P, van der Bom J G, Leebeek F W G, Rijken D C, Uitte de Willige S
Abstract excerpt
INTRODUCTION: von Willebrand disease (VWD) is the most common inherited bleeding disorder. In VWD patients, large variations in bleeding tendency are observed, which cannot be completely explained by the variation in von Willebrand factor levels or activities. Thus, there must be additional factors, for instance, changes in fibrinolysis that have an effect on the variation in bleeding tendency in VWD patients....
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