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Article

Digital PCR: A Sensitive and Precise Method for KIT D816V Quantification in Mastocytosis.

Clinical chemistry - 1 Mar 2018

Greiner Georg, Gurbisz Michael, Ratzinger Franz, Witzeneder Nadine, Simonitsch-Klupp Ingrid, Mitterbauer-Hohendanner Gerlinde, Mayerhofer Matthias, Müllauer Leonhard, Sperr Wolfgang R, Valent Peter, Hoermann Gregor

Abstract excerpt

BACKGROUND: The analytically sensitive detection of KIT D816V in blood and bone marrow is important for diagnosing systemic mastocytosis (SM). Additionally, precise quantification of the KIT D816V variant allele fraction (VAF) is relevant clinically because it helps to predict multilineage involvement and prognosis in cases of advanced SM. Digital PCR (dPCR) is a promising new method for sensitive detection and...

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Share to Bone Marrow
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29237714
DOI: 10.1373/clinchem.2017.277897
PMCID: PMC7115889

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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