Making Connections: p53 and the Cathepsin Proteases as Co-Regulators of Cancer and Apoptosis

Abstract excerpt

While viewed as the "guardian of the genome", the importance of the tumor suppressor p53 protein has increasingly gained ever more recognition in modulating additional modes of action related to cell death. Slowly but surely, its importance has evolved from a mutated genetic locus heavily implicated in a wide array of cancer types to modulating lysosomal-mediated cell death either directly or indirectly through...

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