Article
p53 and apoptosis: it's not just in the nucleus anymore.
Molecular cell - 1 Mar 2003
Manfredi James J
Abstract excerpt
The tumor suppressor p53 triggers apoptosis in response to a variety of stress stimuli. Its role as a transcription factor modulating gene expression has been clearly implicated in this process. Two recent publications now argue for an additional direct role of p53 at the mitochondria in inducing apoptosis.
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