Article
Analysis of cell cycle-related proteins in gastric intramucosal differentiated-type cancers based on mucin phenotypes: a novel hypothesis of early gastric carcinogenesis based on mucin phenotype.
BMC gastroenterology - 7 Jun 2010
Sugai Tamotsu, Tsukahara Mitsunori, Endoh Masaki, Shioi Yoshihiro, Takebe Noriko, Mue Yoshiharu, Matsushita Hiroo, Toyota Minoru, Suzuki Kazuyuki
Abstract excerpt
BACKGROUND: Abnormalities of cell cycle regulators are common features in human cancers, and several of these factors are associated with the early development of gastric cancers. However, recent studies have shown that gastric cancer tumorigenesis was characterized by mucin expression. Thus, expression patterns of cell cycle-related proteins were investigated in the early phase of differentiated-type gastric...
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