Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular dynamics simulations demonstrate the regulation of DNA-DNA attraction by H4 histone tail acetylations and mutations.

Biopolymers - 1 Oct 2014

Korolev Nikolay, Yu Hang, Lyubartsev Alexander P, Nordenskiöld Lars

Abstract excerpt

The positively charged N-terminal histone tails play a crucial role in chromatin compaction and are important modulators of DNA transcription, recombination, and repair. The detailed mechanism of the interaction of histone tails with DNA remains elusive. To model the unspecific interaction of histone tails with DNA, all-atom molecular dynamics (MD) simulations were carried out for systems of four DNA 22-mers in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cations
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Peptides

Source

Identifiers

PMID: 24740714
DOI: 10.1002/bip.22499

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular dynamics simulations demonstrate the regulation of DNA-DNA attraction by H4 histone tail acetylations and mutations.PMID 24740714Read ↗

Binding of regulatory proteins to nucleosomes is modulated by dynamic histone tailsSemantic proximity Read ↗

Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations.Semantic proximity Read ↗

Structural and thermodynamic impact of oncogenic mutations on the nucleosome core particle.Semantic proximity Read ↗

A Dynamic View of the Interaction of Histone Tails with Clustered Abasic Sites in a Nucleosome Core Particle.Semantic proximity Read ↗

The effects of histone H4 tail acetylations on cation-induced chromatin folding and self-association.Semantic proximity Read ↗

Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.Semantic proximity Read ↗

Metal ion interactions with DNA: considerations on structure, stability, and effects from metal ion binding.Semantic proximity Read ↗

Dynamics of the nucleosomal histone H3 N-terminal tail revealed by high precision single-molecule FRET.Semantic proximity Read ↗

Influence of histone tails and H4 tail acetylations on nucleosome-nucleosome interactions.Semantic proximity Read ↗

The "sugar" coarse-grained DNA model.Semantic proximity Read ↗

Predicting the Three-dimensional Structure of the c- <i>KIT</i> Oncogene Promoter and the Dynamics of Strongly Coupled Guanine-QuadruplexesSemantic proximity Read ↗

Sliding of p53 along DNA can be modulated by its oligomeric state and by cross-talks between its constituent domains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.