Article
Increasing consistency of disease biomarker prediction across datasets.
PloS one - 1 Jan 2014
Chikina Maria D, Sealfon Stuart C
Abstract excerpt
Microarray studies with human subjects often have limited sample sizes which hampers the ability to detect reliable biomarkers associated with disease and motivates the need to aggregate data across studies. However, human gene expression measurements may be influenced by many non-random factors such as genetics, sample preparations, and tissue heterogeneity. These factors can contribute to a lack of agreement...
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