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Article

A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine.

PloS one - 1 Jan 2014

Kimber Scott T, Brown Tom, Fox Keith R

Abstract excerpt

We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme's active site. Uracil is selected over cytosine by a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24740413
DOI: 10.1371/journal.pone.0095394
PMCID: PMC3989344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24740413-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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