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Article

Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain.

Human psychopharmacology - 1 Jul 2014

Gagliano Sarah A, Tiwari Arun K, Freeman Natalie, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L, Knight Jo, Müller Daniel J

Abstract excerpt

OBJECTIVE: Antipsychotics are effective in treating schizophrenia symptoms. However, the use of clozapine and olanzapine in particular are associated with significant weight gain. Mouse and human studies suggest that the protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene may be involved in energy metabolism, and there is evidence that it is associated with clozapine's effects on triglyceride...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24737441
DOI: 10.1002/hup.2407

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