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Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s disease

14 Feb 2016

Abstract excerpt

Paget's disease (PD) is characterized by focal and dramatic bone resorption and formation. Treatments that target osteoclasts (OCLs) block both pagetic bone resorption and formation; therefore, PD offers key insights into mechanisms that couple bone resorption and formation. Here, we evaluated OCLs from 3 patients with PD and determined that measles virus nucleocapsid protein (MVNP) was expressed in 70% of these...

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PMID: 26878170
DOI: 10.1172/jci82012

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