Article
Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants.
The Biochemical journal - 25 Jun 2021
Okamura Eiji, Ohtaka Kinuka, Nishihama Ryuichi, Uchida Kai, Kuwahara Ayuko, Mochida Keiichi, Hirai Masami Yokota
Abstract excerpt
The phosphorylated pathway of serine biosynthesis is initiated with 3-phosphoglycerate dehydrogenase (PGDH). The liverwort Marchantia polymorpha possesses an amino acid-sensitive MpPGDH which is inhibited by l-serine and activated by five proteinogenic amino acids, while the eudicot Arabidopsis thaliana has amino acid-sensitive AtPGDH1 and AtPGDH3 as well as amino acid-insensitive AtPGDH2. In this study, we...
Topics
- Allosteric Regulation
- Amino Acid Sequence
- Arabidopsis
- Bryopsida
- Gene Expression Regulation, Plant
- Marchantia
- Mutation
- Oryza
- Phosphoglycerate Dehydrogenase
- Phylogeny
- Plant Proteins
- Sequence Homology
- Serine