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Article

Diversified amino acid-mediated allosteric regulation of phosphoglycerate dehydrogenase for serine biosynthesis in land plants.

The Biochemical journal - 25 Jun 2021

Okamura Eiji, Ohtaka Kinuka, Nishihama Ryuichi, Uchida Kai, Kuwahara Ayuko, Mochida Keiichi, Hirai Masami Yokota

Abstract excerpt

The phosphorylated pathway of serine biosynthesis is initiated with 3-phosphoglycerate dehydrogenase (PGDH). The liverwort Marchantia polymorpha possesses an amino acid-sensitive MpPGDH which is inhibited by l-serine and activated by five proteinogenic amino acids, while the eudicot Arabidopsis thaliana has amino acid-sensitive AtPGDH1 and AtPGDH3 as well as amino acid-insensitive AtPGDH2. In this study, we...

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Identifiers

PMID: 34032263
DOI: 10.1042/BCJ20210191
PMCID: PMC8238522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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