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Article

Double mutation of cell wall proteins CspB and PBP1a increases secretion of the antibody Fab fragment from Corynebacterium glutamicum.

Microbial cell factories - 15 Apr 2014

Matsuda Yoshihiko, Itaya Hiroshi, Kitahara Yuki, Theresia Natalia Maria, Kutukova Ekaterina Aleksandrovna, Yomantas Yurgis Antanas Vladovich, Date Masayo, Kikuchi Yoshimi, Wachi Masaaki

Abstract excerpt

BACKGROUND: Among other advantages, recombinant antibody-binding fragments (Fabs) hold great clinical and commercial potential, owing to their efficient tissue penetration compared to that of full-length IgGs. Although production of recombinant Fab using microbial expression systems has been reported, yields of active Fab have not been satisfactory. We recently developed the Corynebacterium glutamicum protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24731213
DOI: 10.1186/1475-2859-13-56
PMCID: PMC4021378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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