Article
Association of DNA base excision repair genes (OGG1, APE1 and XRCC1) polymorphisms with outcome to platinum-based chemotherapy in advanced nonsmall-cell lung cancer patients.
International journal of cancer - 1 Dec 2014
Peng Yu, Li Zheng, Zhang Shiheng, Xiong Yanli, Cun Yanping, Qian Chengyuan, Li Mengxia, Ren Tao, Xia Lei, Cheng Yi, Wang Dong
Abstract excerpt
Polymorphism of DNA base excision repair (BER) genes affects DNA repair capacity and may alter sensitivity to platinum-based chemotherapy regimens. This study investigated polymorphisms of OGG1 Ser326Cys, APE1 Asp148Glu APE1-141T/G and XRCC1 Arg399Gln for association with clinical outcome in 235 advanced inoperable nonsmall-cell lung cancer (NSCLC) patients after treatment with platinum-based chemotherapy. The...
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