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Article

Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Oct 2000

Jenkinson C P, Hanson R, Cray K, Wiedrich C, Knowler W C, Bogardus C, Baier L

Abstract excerpt

OBJECTIVES: To investigate whether (a) variants within the dopamine D2 receptor gene (DRD2) are associated with obesity and type 2 diabetes in Pima Indians, and (b) whether variation in this gene could be responsible for previously observed linkage to these phenotypes, at chromosome location 11q2...

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Source

Identifiers

PMID: 11093282
DOI: 10.1038/sj.ijo.0801381

Genes

DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11093282-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Association of dopamine D2 receptor polymorphisms Ser311Cys and TaqIA with obesity or type 2 diabetes mellitus in Pima Indians.PMID 11093282Read ↗

An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians.Semantic proximity Read ↗

Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians.Semantic proximity Read ↗

The Taq IA and Ser311 Cys polymorphisms in the dopamine D2 receptor gene and obesity.Semantic proximity Read ↗

Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA.Semantic proximity Read ↗

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Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians.Semantic proximity Read ↗

The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Linkage and association of a functional DRD2 variant [Ser311Cys] and DRD2 markers to alcoholism, substance abuse and schizophrenia in Southwestern American Indians.Semantic proximity Read ↗

Genome-wide linkage analysis assessing parent-of-origin effects in the inheritance of type 2 diabetes and BMI in Pima Indians.Semantic proximity Read ↗

11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.Semantic proximity Read ↗

Protein tyrosine phosphatase 1B is not a major susceptibility gene for type 2 diabetes mellitus or obesity among Pima Indians.Semantic proximity Read ↗

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians.Semantic proximity Read ↗

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