Article
Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension.
Nature communications - 15 Apr 2015
Newman John H, Holt Timothy N, Cogan Joy D, Womack Bethany, Phillips John A, Li Chun, Kendall Zachary, Stenmark Kurt R, Thomas Milton G, Brown R Dale, Riddle Suzette R, West James D, Hamid Rizwan
Abstract excerpt
High-altitude pulmonary hypertension (HAPH) has heritable features and is a major cause of death in cattle in the Rocky Mountains, USA. Although multiple genes are likely involved in the genesis of HAPH, to date no major gene variant has been identified. Using whole-exome sequencing, we report the high association of an EPAS1 (HIF2α) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with...
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