Article
The interleukin-6-174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study.
Vascular health and risk management - 1 Jan 2008
Sie Mark P S, Mattace-Raso Francesco U S, Uitterlinden André G, Arp Pascal P, Hofman Albert, Pols Huibert A P, Hoeks Arnold P G, Reneman Robert S, Asmar Roland, van Duijn Cornelia M, Witteman Jacqueline C M
Abstract excerpt
Arterial stiffness normally increases with age and has been established as a precursor of cardiovascular disease. Interleukin-6 is a pleiotropic inflammatory cytokine with an important role in the inflammatory cascade, such as up-regulation of C-reactive protein (CRP). The interleukin-6-174-G/C promoter polymorphism appears to influence levels of inflammatory markers, which have been shown to be associated with...
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