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Article

Asymmetric division of clonal muscle stem cells coordinates muscle regeneration in vivo.

Science (New York, N.Y.) - 8 Jul 2016

Gurevich David B, Nguyen Phong Dang, Siegel Ashley L, Ehrlich Ophelia V, Sonntag Carmen, Phan Jennifer M N, Berger Silke, Ratnayake Dhanushika, Hersey Lucy, Berger Joachim, Verkade Heather, Hall Thomas E, Currie Peter D

Abstract excerpt

Skeletal muscle is an example of a tissue that deploys a self-renewing stem cell, the satellite cell, to effect regeneration. Recent in vitro studies have highlighted a role for asymmetric divisions in renewing rare "immortal" stem cells and generating a clonal population of differentiation-competent myoblasts. However, this model currently lacks in vivo validation. We define a zebrafish muscle stem cell...

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PMID: 27198673
DOI: 10.1126/science.aad9969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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